Clinical performance

of a collagen-based hydroxyapatite bone graft substitute

in procedures of spinal arthrodesis

A. BARBANERA*, M. VITALI**, A. NATALONI**, V. CANELLA*

* Division of Neurosurgery, “SS. Antonio and Biagio and Cesare Arrigo” Hospital, Alessandria, Italy
** Clinical Department, Fin-Ceramica, Faenza, Italy

Summary

Progress in Neuroscience 2020; 5 (1-4): 3-9.

AIMS. Spinal fusion is a common procedure used for surgical treatment of spinal deformity. In
recent years, many bone graft substitutes have been developed to provide good arthrodesis when the available autologous bone harvested from the patient is not enough. Besides, bioactive synthetics have undergone changes to stimulate a beneficial response within the bone, which are based on chemical reactions allowing cellular turnover and the enhancement of new bone formation. In this context, a collagen-based hydroxyapatite bone graft substitute enriched in magnesium has shown promising results in achieving fusion for the treatment of adult scoliosis. Aim of the present clinical study was to evaluate the performance and safety of a collagenbased
hydroxyapatite bone graft substitute enriched in Magnesium, to stimulate bony fusion in patients
undergoing posterolateral spinal fusion.
MATERIALS AND METHODS. Twenty patients were consecutively enrolled and prospectively evaluated. Patients underwent instrumented posterolateral spinal fusion using a biomimetic hydroxyapatite composite scaffold. Radiological evaluations were performed at 12 months follow-up to evaluate fusion. RESULTS. The percentage of bony fusion recorded was of 95% at twelve months follow-up. No intra-operative or post-operative adverse events were recorded.
CONCLUSIONS. The present study provides clinical evidences of the fusion properties of a collagen-based HA scaffold, enriched in magnesium, for posterolateral spinal fusion. The safety profile and the osteointegrative properties makes the device a valid alternative to local autograft bone.

KEY WORDS: Bioinorganic ions, Bone graft substitutes, Mg-enriched hydroxyapatite, Posterolateral fusion.

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